Antibody-Binding Proteins and Conjugates
Cayman Chemical GluCys ammonium salt 50mg
An intermediate in GSH synthesis; formed by ATP-dependent condensation of cysteine and glutamate by γ-glutamylcysteine synthetase; an essential component of phytochelatins
Cayman Chemical BIctegravIrsodIum salt 50mg
An HIV-1 integrase inhibitor (IC50 = 7.5 nM for strand transfer activity); has antiviral activity against clinical isolates of HIV-1 in PBMCs (EC50s = 0.04-1.7 nM); inhibits HIV-1 viral infection in MT-2 and MT-4 cells, CD4+ T cells, and macrophages (EC50s = 1.5, 2.5, 1.5, and 6.6 nM, respectively)
Vmrd Inc Feline Herpesvirus Type 1 (FHV-1/FVR) FITC Conjugate | 10 mL
Anti-Feline Herpesvirus Type 1/Feline Viral Rhinotracheitis (FHV-1/FVR) polyclonal antiserum conjugated to fluorescein isothiocyanate. Feline origin. Useful as an aid in the detection of Feline Viral Rhinotracheitis virus in tissue sections, smears and cultures. Does not stain calicivirus or panleukopenia virus.
Cayman Chemical RosIglItazonpotasIum salt 50mg
A PPARγ agonist; activates PPARγ1 and PPARγ2 in reporter assays (EC50s = 30 and 100 nM, respectively); selectively activates chimeras containing the LBDs of PPARγ over PPARα and PPARδ in a cell-based reporter assay at 10 mM; an inhibitor of ACSL4 (IC50 = 0.5 µM), inhibits RSL3-induced ferroptosis in Pfa1 cells and Pparg KO cells, and increases survival in a Gpx4 KO mouse model of ferroptosis at 0.0125 mg/ml in the drinking water; decreases HbA1c and fasting blood glucose levels in a rat model of type 2 diabetes induced by STZ and a high-carbohydrate and high-fat diet at 4 mg/kg
MORADEC LLC Fab-αHFc-CL-DMDM, 50 μg, Human IgG Fc region specific, Cleavable linker, Alkylates DNA
Fab Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker is a specialized secondary antibody-drug conjugate designed for research applications. This product uniquely combines the Fab fragment of a polyclonal antibody with Duocarmycin DM, a cytotoxic small molecule, to facilitate targeted cell death through DNA alkylation. The cleavable linker ensures stability in extracellular environments and offers selective activation within cells for enhanced delivery of therapeutic agents. This approach creates opportunities for innovative antibody lead screening in ADC development.
- Target specificity for the human IgG Fc region
- Monovalent nature of the Fab fragment
- Stability in extracellular fluid
- Cleavable linker activated by intracellular cathepsins
- Alkylation mechanism targeting DNA minor groove
- Suitable for antibody pre-screening applications
- 50 μg quantity available
Cayman Chemical TInptInsodIum salt 500mg
An atypical antidepressant; an agonist of MORs (EC50s = 194 and 641 nM for human and mouse receptors in a BRET assay for G protein activation; decreases immobility in the forced swim test in wild-type, but not MOR knockout mice at 30 mg/kg; increases locomotor activity at a dose of 30, but not 10 mg/kg, in the open field test; prevents increases in chronic restraint stress-induced GLT-1 expression in the rat hippocampal CA3 region at 10 mg/kg per day for 21 days
Cayman Chemical PIrIprostpotasIum salt 50mg
Piriprost is a structural analog of PGI2 with low IP receptor-mediated activity. Piriprost inhibits 5-LO with an IC50 value around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells.{994} Piriprost inhibits the release of histamine and leukotrienes from isolated porcine lung cells with an IC50 value of 0.11 µM.{4708}
Cayman Chemical CefonIcIdodIum salt 500mg
A broad-spectrum antibiotic with a prolonged serum elimination half-life in animals
Abcam PE/Texas Red Conjugation Kit - Lightning-Link
PE/Texas Red Conjugation Kit - Lightning-Link
The product is subject to the following: Abcam Restricted Use Statement
Electron Microscopy Sciences Aurion ImmunoGold EM Gam-6/Gar-10.Bsa-C Kit
Immunogold reagent kit. Two non-overlapping gold particle sizes. Coupled to either Goat-anti-Rabbit and Goat-anti-Mouse IgG/IgM antibodies, includes: 1ml Goat-anti-Mouse IgG/IgM 6 nm, 1ml Goat-anti-Rabbit 10 nm, 30ml BSA-c